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            This study examined the application of GPT-4 with vision (GPT-4V), a multimodal large language model with visual recognition, in detecting radiologic findings from a set of 100 chest radiographs and suggests that GPT-4V is currently not ready for real-world diagnostic usage in interpreting chest radiographs.more » « less
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            Pyrros, Ayis; Borstelmann, Stephen M; Mantravadi, Ramana; Zaiman, Zachary; Thomas, Kaesha; Price, Brandon; Greenstein, Eugene; Siddiqui, Nasir; Willis, Melinda; Shulhan, Ihar; et al (, Nature Communications)Abstract Deep learning (DL) models can harness electronic health records (EHRs) to predict diseases and extract radiologic findings for diagnosis. With ambulatory chest radiographs (CXRs) frequently ordered, we investigated detecting type 2 diabetes (T2D) by combining radiographic and EHR data using a DL model. Our model, developed from 271,065 CXRs and 160,244 patients, was tested on a prospective dataset of 9,943 CXRs. Here we show the model effectively detected T2D with a ROC AUC of 0.84 and a 16% prevalence. The algorithm flagged 1,381 cases (14%) as suspicious for T2D. External validation at a distinct institution yielded a ROC AUC of 0.77, with 5% of patients subsequently diagnosed with T2D. Explainable AI techniques revealed correlations between specific adiposity measures and high predictivity, suggesting CXRs’ potential for enhanced T2D screening.more » « less
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            Pyrros, Ayis; Chen, Andrew; Rodríguez-Fernández, Jorge Mario; Borstelmann, Stephen M.; Cole, Patrick A; Horowitz, Jeanne; Chung, Jonathan; Nikolaidis, Paul; Boddipalli, Viveka; Siddiqui, Nasir; et al (, Academic Radiology)
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